Artegiani & Hendriks group
Human brain and liver models
The Artegiani & Hendriks research group aims to contribute to the understanding of the early steps of tumorigenesis: how and why do tumors originate?
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Benedetta Artegiani
Delilah Hendriks
We develop and use complex human organoid models to elucidate the mechanisms by which initially normal cells, as well as chronically diseased cells, transform into cancer cells. We apply, amongst others, CRISPR engineering approaches to engineer healthy cells with specific mutations and study possible alterations these cells might hijack to form a tumor. We have a specific focus on brain and liver cancers. As developmental processes and cancer, especially pediatric ones, are deeply interconnected, we have also a particular focus on understanding how transformed cells can exploit developmental mechanisms to their advantage.
“How and why do tumors arise? We aim to answer these questions by gaining a better understanding of the early steps of tumor formation”
Benedetta Artegiani en Delilah Hendriks
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