Kool groep

Beurzen en publicaties

• Beurzen

  • Modelling Embryonal Brain Tumors with BCOR Alterations for Understanding Biology and Therapy - KiKa project grant (2024 - 2028)

  •  Improving treatments for patients with rare embryonal and sarcomatous CNS tumours – Quest for Cures: Collaborative Discovery Teams program grant – The Brain Tumour Charity UK (2024 - 2029) – with Katja Hoff von Hoff (Aarhus), Barry Pizer (Liverpool), Darren Hargrave (London), Jan Koster (Amsterdam) and Johannes Gojo (Vienna)

  • MIMIC 2.0 – Myeloid cell targeting to enhance T-cell immunotherapy in pediatric high-grade brain cancers - KiKa project grant (2024 - 2028) - with Jasper van der Lugt, Nierkens Group and Stunnenberg Group

  • Ependymoma models and drug screening - Ependymoma Research Foundation (2024-2025)

  • Generation, characterization and testing of new preclinical models for rare brain tumor types - Oncode Accelerator Brain Program  (2024-2026)

  • Exploring Unknown Relapse Origins in Paediatric Ependymoma (EUROPE) – Fight Kids Cancer project grant (2024 - 2028) – with Kristian Pajtler (KiTZ), Abigail Suwala (Heidelberg) and Ülrich Schüller (Hamburg) and Johannes Gojo (Vienna)

  • The ITCC Brain Translational Accelerator Platform – Fight Kids Cancer project grant (2024 - 2028) – with David Jones / Kristian Pajtler (KiTZ), Steve Clifford/Gareth Veal (Newcastle), Chris Jones (London) and Johannes Gojo (Vienna)

  • Cerebellar Organoid Modelling of Medulloblastoma to Accelerate New Discoveries (COMMAND) – Quest for Cures: Collaborative Discovery Teams program grant – The Brain Tumour Charity UK (2023 - 2028) – with Esther Becker (NCDN, Oxford), Lena Kütscher (KiTZ, Heidelberg) and Paul Northcott (St Jude, Memphis)

  • Genetically modified cerebellar organoids as models for sonic hedgehog medulloblastoma - KiKa project grant (2022 - 2025)

  • High-throughput drug screens on PDX-derived organoids for posterior fossa A ependymoma – Stichting STOPHersentumoren.nl (2022 - 2023)

  • ITCC-P4 MIRROR project with the Molenaar Group and other groups in the Máxima

  • Marie Sklodowska-Curie COFUND – Máxima Butterfly Program with 25 other research groups in the Máxima –News article

  • Brain tumor organoids as models for pediatric brain tumors - KiKa fast track grant (2019 - 2023)

  Twinning program KiTZ

  • Personalized drug sensitivity profiling– with Molenaar Group and other groups in KiTZ and the Máxima

  • KITZ-Máxima PDX pipeline – with various groups in KiTZ and the Máxima

• Belangrijkste publicaties

  • D.T. Jones*, N. Jager*, M. Kool, T. Zichner, B. Hutter, M. Sultan, Y.J. Cho, T.J. Pugh, V. Hovestadt, A.M. Stutz, T. Rausch, H.J. Warnatz, M. Ryzhova, S. Bender, D. Sturm, S. Pleier, H. Cin, E. Pfaff, L. Sieber, A. Wittmann, M. Remke, H. Witt, S. Hutter, T. Tzaridis, J. Weischenfeldt, B. Raeder, M. Avci, V. Amstislavskiy, M. Zapatka, U.D. Weber, Q. Wang, B. Lasitschka, C.C. Bartholomae, M. Schmidt, C. von Kalle, V. Ast, C. Lawerenz, J. Eils, R. Kabbe, V. Benes, P. van Sluis, J. Koster, R. Volckmann, D. Shih, M.J. Betts, R.B. Russell, S. Coco, G.P. Tonini, U. Schuller, V. Hans, N. Graf, Y.J. Kim, C. Monoranu, W. Roggendorf, A. Unterberg, C. Herold-Mende, T. Milde, A.E. Kulozik, A. von Deimling, O. Witt, E. Maass, J. Rossler, M. Ebinger, M.U. Schuhmann, M.C. Fruhwald, M. Hasselblatt, N. Jabado, S. Rutkowski, A.O. von Bueren, D. Williamson, S.C. Clifford, M.G. McCabe, V.P. Collins, S. Wolf, S. Wiemann, H. Lehrach, B. Brors, W. Scheurlen, J. Felsberg, G. Reifenberger, P.A. Northcott, M.D. Taylor, M. Meyerson, S.L. Pomeroy, M.L. Yaspo, J.O. Korbel, A. Korshunov, R. Eils*#, S.M. Pfister*#, P. Lichter*, Dissecting the genomic complexity underlying medulloblastoma, Nature, 488 (2012) 100-105.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966/   

  • Kool#, D.T. Jones, N. Jager, P.A. Northcott, T.J. Pugh, V. Hovestadt, R.M. Piro, L.A. Esparza, S.L. Markant, M. Remke, T. Milde, F. Bourdeaut, M. Ryzhova, D. Sturm, E. Pfaff, S. Stark, S. Hutter, H. Seker-Cin, P. Johann, S. Bender, C. Schmidt, T. Rausch, D. Shih, J. Reimand, L. Sieber, A. Wittmann, L. Linke, H. Witt, U.D. Weber, M. Zapatka, R. Konig, R. Beroukhim, G. Bergthold, P. van Sluis, R. Volckmann, J. Koster, R. Versteeg, S. Schmidt, S. Wolf, C. Lawerenz, C.C. Bartholomae, C. von Kalle, A. Unterberg, C. Herold-Mende, S. Hofer, A.E. Kulozik, A. von Deimling, W. Scheurlen, J. Felsberg, G. Reifenberger, M. Hasselblatt, J.R. Crawford, G.A. Grant, N. Jabado, A. Perry, C. Cowdrey, S. Croul, G. Zadeh, J.O. Korbel, F. Doz, O. Delattre, G.D. Bader, M.G. McCabe, V.P. Collins, M.W. Kieran, Y.J. Cho, S.L. Pomeroy, O. Witt, B. Brors, M.D. Taylor, U. Schuller, A. Korshunov, R. Eils, R.J. Wechsler-Reya*, P. Lichter*, S.M. Pfister*, I.P.T. Project, Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition, Cancer Cell, 25 (2014) 393-405. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053/

  • K.W. Pajtler*, H. Witt*, M. Sill*, D.T. Jones, V. Hovestadt, F. Kratochwil, K. Wani, R. Tatevossian, C. Punchihewa, P. Johann, J. Reimand, H.J. Warnatz, M. Ryzhova, S. Mack, V. Ramaswamy, D. Capper, L. Schweizer, L. Sieber, A. Wittmann, Z. Huang, P. van Sluis, R. Volckmann, J. Koster, R. Versteeg, D. Fults, H. Toledano, S. Avigad, L.M. Hoffman, A.M. Donson, N. Foreman, E. Hewer, K. Zitterbart, M. Gilbert, T.S. Armstrong, N. Gupta, J.C. Allen, M.A. Karajannis, D. Zagzag, M. Hasselblatt, A.E. Kulozik, O. Witt, V.P. Collins, K. von Hoff, S. Rutkowski, T. Pietsch, G. Bader, M.L. Yaspo, A. von Deimling, P. Lichter, M.D. Taylor, R. Gilbertson, D.W. Ellison, K. Aldape, A. Korshunov*, M. Kool*#, S.M. Pfister*#, Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups, Cancer Cell, 27 (2015) 728-743.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712639/

  • P.D. Johann*, S. Erkek*, M. Zapatka, K. Kerl, I. Buchhalter, V. Hovestadt, D.T. Jones, D. Sturm, C. Hermann, M. Segura Wang, A. Korshunov, M. Rhyzova, S. Grobner, S. Brabetz, L. Chavez, S. Bens, S. Groschel, F. Kratochwil, A. Wittmann, L. Sieber, C. Georg, S. Wolf, K. Beck, F. Oyen, D. Capper, P. van Sluis, R. Volckmann, J. Koster, R. Versteeg, A. von Deimling, T. Milde, O. Witt, A.E. Kulozik, M. Ebinger, T. Shalaby, M. Grotzer, D. Sumerauer, J. Zamecnik, J. Mora, N. Jabado, M.D. Taylor, A. Huang, E. Aronica, A. Bertoni, B. Radlwimmer, T. Pietsch, U. Schuller, R. Schneppenheim, P.A. Northcott, J.O. Korbel, R. Siebert, M.C. Fruhwald, P. Lichter, R. Eils, A. Gajjar, M. Hasselblatt, S.M. Pfister*, M. Kool*#, Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes, Cancer Cell, 29 (2016) 379-393. https://www.cell.com/cancer-cell/fulltext/S1535-6108(16)30035-6

  • Sturm*, B.A. Orr*, U.H. Toprak*, V. Hovestadt*, D.T. Jones, D. Capper, M. Sill, I. Buchhalter, P.A. Northcott, I. Leis, M. Ryzhova, C. Koelsche, E. Pfaff, S.J. Allen, G. Balasubramanian, B.C. Worst, K.W. Pajtler, S. Brabetz, P.D. Johann, F. Sahm, J. Reimand, A. Mackay, D.M. Carvalho, M. Remke, J.J. Phillips, A. Perry, C. Cowdrey, R. Drissi, M. Fouladi, F. Giangaspero, M. Lastowska, W. Grajkowska, W. Scheurlen, T. Pietsch, C. Hagel, J. Gojo, D. Lotsch, W. Berger, I. Slavc, C. Haberler, A. Jouvet, S. Holm, S. Hofer, M. Prinz, C. Keohane, I. Fried, C. Mawrin, D. Scheie, B.C. Mobley, M.J. Schniederjan, M. Santi, A.M. Buccoliero, S. Dahiya, C.M. Kramm, A.O. von Bueren, K. von Hoff, S. Rutkowski, C. Herold-Mende, M.C. Fruhwald, T. Milde, M. Hasselblatt, P. Wesseling, J. Rossler, U. Schuller, M. Ebinger, J. Schittenhelm, S. Frank, R. Grobholz, I. Vajtai, V. Hans, R. Schneppenheim, K. Zitterbart, V.P. Collins, E. Aronica, P. Varlet, S. Puget, C. Dufour, J. Grill, D. Figarella-Branger, M. Wolter, M.U. Schuhmann, T. Shalaby, M. Grotzer, T. van Meter, C.M. Monoranu, J. Felsberg, G. Reifenberger, M. Snuderl, L.A. Forrester, J. Koster, R. Versteeg, R. Volckmann, P. van Sluis, S. Wolf, T. Mikkelsen, A. Gajjar, K. Aldape, A.S. Moore, M.D. Taylor, C. Jones, N. Jabado, M.A. Karajannis, R. Eils, M. Schlesner, P. Lichter, A. von Deimling, S.M. Pfister, D.W. Ellison*, A. Korshunov*, M. Kool*#, New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs, Cell, 164 (2016) 1060-1072. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621/

  • S.C. Mack*, K.W. Pajtler*, L. Chavez*, K. Okonechnikov, K.C. Bertrand, X. Wang, S. Erkek, A. Federation, A. Song, C. Lee, X. Wang, L. McDonald, J.J. Morrow, A. Saiakhova, P. Sin-Chan, Q. Wu, K.A. Michaelraj, T.E. Miller, C.G. Hubert, M. Ryzhova, L. Garzia, L. Donovan, S. Dombrowski, D.C. Factor, B. Luu, C.L.L. Valentim, R.C. Gimple, A. Morton, L. Kim, B.C. Prager, J.J.Y. Lee, X. Wu, J. Zuccaro, Y. Thompson, B.L. Holgado, J. Reimand, S.Q. Ke, A. Tropper, S. Lai, S. Vijayarajah, S. Doan, V. Mahadev, A.F. Minan, S.N. Grobner, M. Lienhard, M. Zapatka, Z. Huang, K.D. Aldape, A.M. Carcaboso, P.J. Houghton, S.T. Keir, T. Milde, H. Witt, Y. Li, C.J. Li, X.W. Bian, D.T.W. Jones, I. Scott, S.K. Singh, A. Huang, P.B. Dirks, E. Bouffet, J.E. Bradner, V. Ramaswamy, N. Jabado, J.T. Rutka, P.A. Northcott, M. Lupien, P. Lichter, A. Korshunov, P.C. Scacheri, S.M. Pfister, M. Kool*#, M.D. Taylor*#, J.N. Rich*#, Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling, Nature, 553 (2018) 101-105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422/

  • Capper*, D.T.W. Jones*, M. Sill*, V. Hovestadt*, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D.E. Reuss, A. Kratz, A.K. Wefers, K. Huang, K.W. Pajtler, L. Schweizer, D. Stichel, A. Olar, N.W. Engel, K. Lindenberg, P.N. Harter, A.K. Braczynski, K.H. Plate, H. Dohmen, B.K. Garvalov, R. Coras, A. Holsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C. Geisenberger, F.J. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, K. Kannan, A. Tsirigos, W. Bruck, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hanggi, V. Hans, S. Rozsnoki, J.R. Hansford, P. Kohlhof, B.W. Kristensen, M. Lechner, B. Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Muhleisen, W. Mueller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N.G. Gottardo, P.H. Driever, C.M. Kramm, H.L. Muller, S. Rutkowski, K. von Hoff, M.C. Fruhwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C.M. Monoranu, A. Perry, C. Jones, T.S. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V.P. Collins, I. Blumcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P.A. Northcott, W. Paulus, A. Gajjar, G.W. Robinson, M.D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M.A. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schuller, R. Buslei, P. Lichter,M. Kool, C. Herold-Mende, D.W. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. von Deimling*#, S.M. Pfister*#, DNA methylation-based classification of central nervous system tumours, Nature, 555 (2018) 469-474. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218/

  • S.N. Grobner*, B.C. Worst*, J. Weischenfeldt, I. Buchhalter, K. Kleinheinz, V.A. Rudneva, P.D. Johann, G.P. Balasubramanian, M. Segura-Wang, S. Brabetz, S. Bender, B. Hutter, D. Sturm, E. Pfaff, D. Hubschmann, G. Zipprich, M. Heinold, J. Eils, C. Lawerenz, S. Erkek, S. Lambo, S. Waszak, C. Blattmann, A. Borkhardt, M. Kuhlen, A. Eggert, S. Fulda, M. Gessler, J. Wegert, R. Kappler, D. Baumhoer, S. Burdach, R. Kirschner-Schwabe, U. Kontny, A.E. Kulozik, D. Lohmann, S. Hettmer, C. Eckert, S. Bielack, M. Nathrath, C. Niemeyer, G.H. Richter, J. Schulte, R. Siebert, F. Westermann, J.J. Molenaar, G. Vassal, H. Witt, I.P.-S. Project, I.M.-S. Project, B. Burkhardt, C.P. Kratz, O. Witt, C.M. van Tilburg, C.M. Kramm, G. Fleischhack, U. Dirksen, S. Rutkowski, M. Fruhwald, K. von Hoff, S. Wolf, T. Klingebiel, E. Koscielniak, P. Landgraf, J. Koster, A.C. Resnick, J. Zhang, Y. Liu, X. Zhou, A.J. Waanders, D.A. Zwijnenburg, P. Raman, B. Brors, U.D. Weber, P.A. Northcott, K.W. Pajtler, M. Kool, R.M. Piro, J.O. Korbel, M. Schlesner, R. Eils, D.T.W. Jones, P. Lichter, L. Chavez*, M. Zapatka*, S.M. Pfister*#, The landscape of genomic alterations across childhood cancers, Nature, 555 (2018) 321-327. https://www.nature.com/articles/nature25480

  • Lambo, S.N. Grobner, T. Rausch, S.M. Waszak, C. Schmidt, A. Gorthi, J.C. Romero, M. Mauermann, S. Brabetz, S. Krausert, I. Buchhalter, J. Koster, D.A. Zwijnenburg, M. Sill, J.M. Hubner, N. Mack, B. Schwalm, M. Ryzhova, V. Hovestadt, S. Papillon-Cavanagh, J.A. Chan, P. Landgraf, B. Ho, T. Milde, O. Witt, J. Ecker, F. Sahm, D. Sumerauer, D.W. Ellison, B.A. Orr, A. Darabi, C. Haberler, D. Figarella-Branger, P. Wesseling, J. Schittenhelm, M. Remke, M.D. Taylor, M.J. Gil-da-Costa, M. Lastowska, W. Grajkowska, M. Hasselblatt, P. Hauser, T. Pietsch, E. Uro-Coste, F. Bourdeaut, J. Masliah-Planchon, V. Rigau, S. Alexandrescu, S. Wolf, X.N. Li, U. Schuller, M. Snuderl, M.A. Karajannis, F. Giangaspero, N. Jabado, A. von Deimling, D.T.W. Jones, J.O. Korbel, K. von Hoff, P. Lichter, A. Huang, A.J.R. Bishop, S.M. Pfister*, A. Korshunov*,M. Kool*#, The molecular landscape of ETMR at diagnosis and relapse, Nature, 576 (2019) 274-280. https://www.nature.com/articles/s41586-019-1815-x

   * Equal contribution

  # Corresponding author